The Choi’s Lab, also named as "Cellular Immunology Lab" is interested in the molecular and cellular basis of the immune response and immunomodulation in various diseases. Je-Min Choi, Ph.D., and his team study T lymphocytes regarding both how they contribute autoimmunity and how we could modulate their functions for therapeutics in human diseases. T cells are originated from hematopoietic stem cells, matures in the thymus, and plays a central role in immune response. Although large variety of T cell clones are beneficial to fight against diverse pathogens, their possible reactivity to self-antigen should be tightly controlled by central and peripheral tolerance system. Thus, understanding of antigen specific T cell functions and immune tolerance is crucial to understand human diseases caused by abnormalities in immune system like aut ...more >>
Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells
LRR domain of NLRX1 protein delivery by dNP2 inhibits T cell functions and alleviates autoimmune encephalomyelitis.